Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human IgA1 mAb
Ig alpha is the major immunoglobulin class in body secretions It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system In normal adult serum the approximate percentage composition of IgA with respect to is subclasses is IgA1 90% and IgA2 10% In secretory IgA the subclass proportions may approach 50 50 The clinical significance of the subclasses has yet to be determined
ABclonal Technology 488 Rabbit anti-Human IL-17RB
The protein encoded by this gene is a cytokine receptor This receptor specifically binds to IL17B and IL17E but does not bind to IL17 and IL17C This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation which suggested the immunoregulatory activity of this receptor
ABclonal Technology PE Rabbit anti-Human TMPRSS2
This gene encodes a protein that belongs to the serine protease family The encoded protein contains a type II transmembrane domain a receptor class A domain a scavenger receptor cysteine-rich domain and a protease domain Serine proteases are known to be involved in many physiological and pathological processes This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E MERS-CoV SARS-CoV and SARS-CoV-2 (COVID-19 virus) Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human FGFR3 mAb
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family with its amino acid sequence being highly conserved between members and among divergent species FGFR family members differ from one another in their ligand affinities and tissue distribution A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia
ABclonal Technology 594 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein that initiates blood coagulation cascades by acting as a high-affinity receptor for factor VII The complex formed activates specific proteolysis initiating coagulation Unlike other cofactors factor III is fully functional when expressed on cell surfaces like monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor under procoagulatory and proinflammatory conditions and it plays a role in HIV-associated coagulopathy Factor III expression in platelets and monocytes is linked to COVID-19 severity and mortality Congenital deficiency of this factor has not been observed Alternative splicing produces multiple transcript variants
ABclonal Technology PE Rabbit anti-Human CD28 mAb
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 450 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 450 Rabbit anti-Human CD138
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology 647 Rabbit anti-Human CD70
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF27 CD27 It is a surface antigen on activated but not on resting T and B lymphocytes It induces proliferation of costimulated T cells enhances the generation of cytolytic T cells and contributes to T cell activation This cytokine is also reported to play a role in regulating B-cell activation cytotoxic function of natural killer cells and immunoglobulin sythesis
ABclonal Technology 647 Rabbit anti-Human PTH1R
The protein encoded by this gene is a member of the G-protein coupled receptor family 2 This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH) The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system Defects in this receptor are known to be the cause of Jansen s metaphyseal chondrodysplasia (JMC) chondrodysplasia Blomstrand type (BOCD) as well as enchodromatosis Two transcript variants encoding the same protein have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD1B mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail and requires vesicular acidification to bind lipid antigens
ABclonal Technology 647 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology APC Rabbit anti-Human CD1B mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail and requires vesicular acidification to bind lipid antigens
ABclonal Technology 488 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
Apexbio Technology LLC Cy5 Rabbit Anti-Goat IgG (H+L) Antibody 2X1ml
Cy5 Rabbit Anti-Goat IgG HplusL Antibody is a fluorescence-labeled secondary antibody targeting goat immunoglobulin G (IgG) specifically binding both heavy and light chains It is designed for signal amplification in immunological assays by binding to primary goat IgG antibodies enabling sensitive detection of target antigens Cy5 Rabbit Anti-Goat IgG HplusL Antibody exerts its biological activity by binding to goat IgG primary antibodies enabling visualization through the Cy5 fluorophore (excitation/emission 650/670 nm) Based on these properties Cy5 Rabbit Anti-Goat IgG HplusL Antibody holds research potential in immunofluorescence staining flow cytometry western blotting and ELISA applications